Immunogen
The antiserum was produced against synthesized peptide derived from human DNAL4. AA range:1-50
Specificity
Dynein LC 4 Polyclonal Antibody detects endogenous levels of Dynein LC 4 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
IHC: 1/100 - 1/300. ELISA: 1/40000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes an axonemal dynein light chain which functions as a component of the outer dynein arms complex. This complex acts as the molecular motor that provides the force to move cilia in an ATP-dependent manner. The encoded protein is expressed in tissues with motile cilia or flagella and may be involved in the movement of sperm flagella. [provided by RefSeq, Dec 2014],
Function
function:Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity.,similarity:Belongs to the dynein light chain family.,subunit:Consists of at least two heavy chains and a number of intermediate and light chains.,
Protein name
Dynein light chain 4 axonemal
Other name
DNAL4; Dynein light chain 4; axonemal
Fields
>>Amyotrophic lateral sclerosis;>>Huntington disease;>>Pathways of neurodegeneration - multiple diseases
Human protein sequence Database
O96015
Mouse protein sequence database
Q9DCM4
Rat protein sequence database
Cellular localization
Cytoplasm, cytoskeleton, cilium axoneme .
Tissue expression
Lung,Skin,Testis,
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