Molecular weight (DA)
22kD
Immunogen
The antiserum was produced against synthesized peptide derived from human DNAL1. AA range:121-170
Specificity
Dynein LC 1 Polyclonal Antibody detects endogenous levels of Dynein LC 1 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/40000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes an axonemal dynein light chain which functions as a component of the outer dynein arms complex. This complex acts as the molecular motor that provides the force to move cilia in an ATP-dependent manner. The encoded protein is expressed in tissues with motile cilia or flagella and may be involved in the movement of sperm flagella. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Jan 2011],
Function
similarity:Belongs to the dynein light chain LC1-type family.,similarity:Contains 4 LRR (leucine-rich) repeats.,subunit:Interacts with DNAH5.,tissue specificity:Expressed in tissues carrying motile cilia such as testis.,
Protein name
Dynein light chain 1 axonemal
Other name
DNAL1; C14orf168; Dynein light chain 1; axonemal
Fields
>>Amyotrophic lateral sclerosis;>>Huntington disease;>>Pathways of neurodegeneration - multiple diseases
Human protein sequence Database
Q4LDG9
Mouse protein sequence database
Q05A62
Rat protein sequence database
Cellular localization
Cytoplasm, cytoskeleton, cilium axoneme .
Tissue expression
Expressed in tissues carrying motile cilia such as respiratory epithelia, ependyma and testis.
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