Molecular weight (DA)
100kD
Immunogen
The antiserum was produced against synthesized peptide derived from human CNTROB. AA range:591-640
Specificity
Centrobin Polyclonal Antibody detects endogenous levels of Centrobin protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/5000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a centrosomal protein that interacts with BRCA2, and is required for centriole duplication and cytokinesis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011],
Function
developmental stage:Preferentially incorporated into the newly assembled daughter centriole during centriole assembly at the late G1 or early S phase. Remains in the daughter centrioles throughout the cell cycle. At the next cycle of centriole duplication, its amount on the original daughter centriole eventually decreases.,function:Required for centriole duplication. Inhibition of centriole duplication leading to defects in cytokinesis.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,sequence caution:Wrong choice of frame.,subcellular location:Centriole-associated, asymmetrically localizes to the daughter centriole.,subunit:Interacts with LYST.,tissue specificity:Widely expressed (at protein level). Highly expressed in testis. Also expressed in spleen, thymus, prostate, small intestine, colon and peripheral blood leukocytes.,
Other name
CNTROB; LIP8; PP1221; Centrobin; Centrosomal BRCA2-interacting protein; LYST-interacting protein 8
Human protein sequence Database
Q8N137
Mouse protein sequence database
Q8CB62
Rat protein sequence database
Cellular localization
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole . Centriole-associated, asymmetrically localizes to the daughter centriole.
Tissue expression
Widely expressed (at protein level). Highly expressed in testis. Also expressed in spleen, thymus, prostate, small intestine, colon and peripheral blood leukocytes.
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