Molecular weight (DA)
40kD
Immunogen
Synthetic Peptide of CABP
Specificity
The antibody detects endogenous CABP protein
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/40000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
Calcium binding proteins are an important component of calcium mediated cellular signal transduction. This gene encodes a protein that belongs to a subfamily of calcium binding proteins which share similarity to calmodulin. The protein encoded by this gene regulates the gating of voltage-gated calcium ion channels. This protein inhibits calcium-dependent inactivation and supports calcium-dependent facilitation of ion channels containing voltage-dependent L-type calcium channel subunit alpha-1C. This protein also regulates calcium-dependent activity of inositol 1,4,5-triphosphate receptors, P/Q-type voltage-gated calcium channels, and transient receptor potential channel TRPC5. This gene is predominantly expressed in retina and brain. Alternative splicing results in multiple transcript variants encoding disinct isoforms. [provided by RefSeq, Jul 2012],
Function
alternative products:Experimental confirmation may be lacking for some isoforms,similarity:Contains 4 EF-hand domains.,subcellular location:L-CaBP1 is associated most likely with the cytoskeletal structures, whereas S-CaBP1 is localized at or near the plasma membrane.,subunit:Interacts with MYO1C.,tissue specificity:Retina and brain. Calbrain was found exclusively in brain where it is abundant in the hippocampus, habenular area in the epithalamus and in the cerebellum.,
Protein name
Calcium-binding protein 1 (CaBP1) (Calbrain) (Caldendrin)
Other name
Calcium-binding protein 1 (CaBP1;Calbrain;Caldendrin)
Human protein sequence Database
Q9NZU7
Mouse protein sequence database
Q9JLK7
Rat protein sequence database
O88751
Cellular localization
Cytoplasm, cytoskeleton . Cytoplasm, perinuclear region . Cell membrane ; Lipid-anchor; Cytoplasmic side. Golgi apparatus . Cell junction, synapse, postsynaptic density . L-CaBP1 is associated most likely with the cytoskeletal structures, whereas S-CaBP1 is localized at or near the plasma membrane. .; [Isoform L-CaBP1]: Cytoplasm, cytoskeleton . L-CaBP1 is associated most likely with the cytoskeletal structures. .; [Isoform S-CaBP1]: Cytoplasm, cell cortex. Cell membrane ; Lipid-anchor . S-CaBP1 is localized at or near the plasma membrane.
Tissue expression
Retina and brain. Somatodendritic compartment of neurons. Calbrain was found exclusively in brain where it is abundant in the hippocampus, habenular area in the epithalamus and in the cerebellum.
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