Molecular weight (DA)
50kD
Immunogen
Synthetic Peptide of β II Tubulin AA range: 80-130
Specificity
The antibody detects endogenous β II tubulin protein.
Formulation
PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.
Dilution rate
WB 1:500-2000; IF/ICC 1:100-500
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using specific immunogen.
Background
Microtubules, key participants in processes such as mitosis and intracellular transport, are composed of heterodimers of alpha- and beta-tubulins. The protein encoded by this gene is a beta-tubulin. Defects in this gene are associated with complex cortical dysplasia with other brain malformations-5. Two transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2015],
Function
function:Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain.,similarity:Belongs to the tubulin family.,subunit:Dimer of alpha and beta chains.,
Protein name
Tubulin beta-2A chain
Abbreviation
Tubulin β II
Other name
Tubulin beta-2A chain
Fields
>>Phagosome;>>Gap junction;>>Alzheimer disease;>>Parkinson disease;>>Amyotrophic lateral sclerosis;>>Huntington disease;>>Prion disease;>>Pathways of neurodegeneration - multiple diseases;>>Pathogenic Escherichia coli infection;>>Salmonella infection
Human protein sequence Database
Q13885
Mouse protein sequence database
Q7TMM9
Rat protein sequence database
P85108
Cellular localization
Cytoplasm, cytoskeleton .
Tissue expression
High expression in brain, where it represents 30% of all beta-tubulins.
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