Molecular weight (DA)
65kD
Immunogen
Synthetic peptide from human protein at AA range: 210-260
Specificity
The antibody detects endogenous Mox1
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000,IHC-p 1:500-200, ELISA 1:10000-20000. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the NADPH oxidase family of enzymes responsible for the catalytic one-electron transfer of oxygen to generate superoxide or hydrogen peroxide. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2012],
Function
cofactor:FAD .,cofactor:NADP .,enzyme regulation:The oxidase activity is potentiated by NOXA1 and NOXO1.,function:NOH-1S is a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes and other tissues. It participates in the regulation of cellular pH and is blocked by zinc. NOH-1L is a pyridine nucleotide-dependent oxidoreductase that generates superoxide and might conduct H(+) ions as part of its electron transport mechanism, whereas NOH-1S does not contain an electron transport chain.,similarity:Contains 1 FAD-binding FR-type domain.,similarity:Contains 1 ferric oxidoreductase domain.,subunit:NOX1, NOXA1, NOXO1, RAC1 and CYBA forms a functional multimeric complex supporting ROS production. Interacts with NOXA1 and NOXO1.,tissue specificity:NOH-1L is detected in colon, uterus, prostate, and colon carcinoma, but not in peripheral blood leukocytes. NOH-1S is dete
Protein name
NADPH oxidase 1 (NOX-1) (EC 1.-.-.-) (Mitogenic oxidase 1) (MOX-1) (NADH/NADPH mitogenic oxidase subunit P65-MOX) (NOH-1)
Other name
NADPH oxidase 1 (NOX-1;EC 1.-.-.-;Mitogenic oxidase 1;MOX-1;NADH/NADPH mitogenic oxidase subunit P65-MOX;NOH-1)
Fields
>>Osteoclast differentiation;>>AGE-RAGE signaling pathway in diabetic complications;>>Alzheimer disease;>>Pathways of neurodegeneration - multiple diseases;>>Chemical carcinogenesis - reactive oxygen species;>>Lipid and atherosclerosis;>>Fluid shear stress and atherosclerosis
Human protein sequence Database
Q9Y5S8
Mouse protein sequence database
Q8CIZ9
Rat protein sequence database
Q9WV87
Cellular localization
Cell projection, invadopodium membrane ; Multi-pass membrane protein . Cell membrane .
Tissue expression
NOH-1L is detected in colon, uterus, prostate, and colon carcinoma, but not in peripheral blood leukocytes. NOH-1S is detected only in colon and colon carcinoma cells.
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