Molecular weight (DA)
33kD
Immunogen
Synthesized peptide derived from ASAH3L . at AA range: 50-130
Specificity
ASAH3L Polyclonal Antibody detects endogenous levels of ASAH3L protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC-p: 1:100-1:300. ELISA: 1/10000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The sphingolipid metabolite sphingosine-1-phosphate promotes cell proliferation and survival, whereas its precursor, sphingosine, has the opposite effect. The ceramidase ACER2 hydrolyzes very long chain ceramides to generate sphingosine (Xu et al., 2006 [PubMed 16940153]).[supplied by OMIM, Jul 2010],
Function
catalytic activity:N-acylsphingosine + H(2)O = a carboxylate + sphingosine.,function:Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.,similarity:Belongs to the alkaline ceramidase family.,
Protein name
Alkaline ceramidase 2
Other name
ACER2; ASAH3L; PP11646; Alkaline ceramidase 2; AlkCDase 2; Alkaline CDase 2; haCER2; Acylsphingosine deacylase 3-like; N-acylsphingosine amidohydrolase 3-like
Fields
>>Sphingolipid metabolism;>>Metabolic pathways;>>Sphingolipid signaling pathway
Human protein sequence Database
Q5QJU3
Mouse protein sequence database
Q8VD53
Rat protein sequence database
Cellular localization
Golgi apparatus membrane ; Multi-pass membrane protein .
Tissue expression
Highly expressed in placenta.
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