Molecular weight (DA)
22kD
Immunogen
The antiserum was produced against synthesized peptide derived from human KCY. AA range:1-50
Specificity
UMP-CMP Kinase Polyclonal Antibody detects endogenous levels of UMP-CMP Kinase protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes one of the enzymes required for cellular nucleic acid biosynthesis. This enzyme catalyzes the transfer of a phosphate group from ATP to CMP, UMP, or dCMP, to form the corresponding diphosphate nucleotide. Alternate splicing results in both coding and non-coding transcript variants. [provided by RefSeq, Feb 2012],
Function
catalytic activity:ATP + (d)CMP = ADP + (d)CDP.,cofactor:Magnesium.,function:Catalyzes specific phosphoryl transfer from ATP to UMP and CMP.,similarity:Belongs to the adenylate kinase family.,subcellular location:Mainly nuclear.,tissue specificity:Ubiquitously expressed.,
Protein name
UMP-CMP kinase
Abbreviation
UMP-CMP Kinase
Other name
CMPK1; CMK; CMPK; UCK; UMK; UMPK; UMP-CMP kinase; Cytidine monophosphate kinase; Cytidylate kinase; Deoxycytidylate kinase; Uridine monophosphate kinase; Uridine monophosphate/cytidine monophosphate kinase; UMP/CMP kinase; UMP/CMPK
Fields
>>Pyrimidine metabolism;>>Drug metabolism - other enzymes;>>Metabolic pathways;>>Nucleotide metabolism;>>Biosynthesis of cofactors
Human protein sequence Database
P30085
Mouse protein sequence database
Q9DBP5
Rat protein sequence database
Q4KM73
Cellular localization
Nucleus . Cytoplasm . Predominantly cytoplasmic, less than 15% nuclear. .
Tissue expression
Ubiquitously expressed.
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