Molecular weight (DA)
70kD
Immunogen
The antiserum was produced against synthesized peptide derived from human UBQLN3. AA range:271-320
Specificity
Ubiquilin-3 Polyclonal Antibody detects endogenous levels of Ubiquilin-3 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/40000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
Summary: This gene encodes an ubiquitin-like protein (ubiquilin) that shares high degree of similarity with related products in yeast, rat and frog. Ubiquilins contain a N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases, and thus thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. This gene is specifically expressed in the testis, and proposed to regulate cell-cycle progression during spermatogenesis. [provided by RefSeq, Jul 2008],
Function
similarity:Contains 1 UBA domain.,similarity:Contains 1 ubiquitin-like domain.,tissue specificity:Testis specific.,
Other name
UBQLN3; Ubiquilin-3
Fields
>>Protein processing in endoplasmic reticulum;>>Amyotrophic lateral sclerosis
Human protein sequence Database
Q9H347
Mouse protein sequence database
Q8C5U9
Rat protein sequence database
Tissue expression
Testis specific.
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