Molecular weight (DA)
73kD
Immunogen
The antiserum was produced against synthesized peptide derived from human SENP1. AA range:1-50
Specificity
SENP1 Polyclonal Antibody detects endogenous levels of SENP1 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/20000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a cysteine protease that specifically targets members of the small ubiquitin-like modifier (SUMO) protein family. This protease regulates SUMO pathways by deconjugating sumoylated proteins. This protease also functions to process the precursor SUMO proteins into their mature form. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012],
Function
function:Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. Deconjugates SUMO1 from HIPK2. Deconjugates SUMO1 from HDAC1, which decreases its transcriptional repression activity.,similarity:Belongs to the peptidase C48 family.,subcellular location:Shuttles between cytoplasm and nucleus.,tissue specificity:Highly expressed in testis. Expressed at lower levels in thymus, pancreas, spleen, liver, ovary and small intestine.,
Protein name
Sentrin-specific protease 1
Other name
SENP1; Sentrin-specific protease 1; Sentrin/SUMO-specific protease SENP1
Human protein sequence Database
Q9P0U3
Mouse protein sequence database
P59110
Rat protein sequence database
Cellular localization
Nucleus . Cytoplasm. Shuttles between cytoplasm and nucleus.
Tissue expression
Highly expressed in testis. Expressed at lower levels in thymus, pancreas, spleen, liver, ovary and small intestine.
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