Molecular weight (DA)
36kD
Immunogen
The antiserum was produced against synthesized peptide derived from human NEURL2. AA range:99-148
Specificity
Neuralized-2 Polyclonal Antibody detects endogenous levels of Neuralized-2 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/40000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a protein that is involved in the regulation of myofibril organization. This protein is likely the adaptor component of the E3 ubiquitin ligase complex in striated muscle, and it regulates the ubiquitin-mediated degradation of beta-catenin during myogenesis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jun 2013],
Function
domain:The SOCS domain mediates the interaction with TCEB1 and TCEB2, while the NHR domain may be involved in ubiquitination substrate binding.,function:Plays an important role in the process of myofiber differentiation and maturation. Probable substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of proteins. Probably contributes to catalysis through recognition and positioning of the substrate and the ubiquitin-conjugating enzyme. During myogenesis, controls the ubiquitination and degradation of the specific pool of CTNNB1/beta-catenin located at the sarcolemma.,pathway:Protein modification; protein ubiquitination.,similarity:Contains 1 NHR (neuralized homology repeat) domain.,similarity:Contains 1 SOCS box domain.,subunit:Probable component the ECS(NEURL2) E3 ubiquitin-protein ligas
Protein name
Neuralized-like protein 2
Abbreviation
Neuralized-2
Other name
NEURL2; C20orf163; Neuralized-like protein 2
Human protein sequence Database
Q9BR09
Mouse protein sequence database
Q9D0S4
Rat protein sequence database
Cellular localization
Cytoplasm .
Tissue expression
Expressed specifically in skeletal and cardiac muscles.
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