Molecular weight (DA)
28kD
Immunogen
The antiserum was produced against synthesized peptide derived from human ELOVL5. AA range:250-299
Specificity
ELOVL5 Polyclonal Antibody detects endogenous levels of ELOVL5 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/40000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene belongs to the ELO family. It is highly expressed in the adrenal gland and testis, and encodes a multi-pass membrane protein that is localized in the endoplasmic reticulum. This protein is involved in the elongation of long-chain polyunsaturated fatty acids. Mutations in this gene have been associated with spinocerebellar ataxia-38 (SCA38). Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2014],
Function
function:May be involved in the elongation of long-chain polyunsaturated fatty acids (PUFAs).,similarity:Belongs to the ELO family.,tissue specificity:Highly expressed in the adrenal gland and testis. Weekly expressed in prostate, lung and brain.,
Protein name
Elongation of very long chain fatty acids protein 5
Other name
ELOVL5; ELOVL2; Elongation of very long chain fatty acids protein 5; 3-keto acyl-CoA synthase ELOVL5; ELOVL fatty acid elongase 5; ELOVL FA elongase 5; Fatty acid elongase 1; hELO1
Fields
>>Fatty acid elongation;>>Biosynthesis of unsaturated fatty acids;>>Metabolic pathways;>>Fatty acid metabolism
Human protein sequence Database
Q9NYP7
Mouse protein sequence database
Q8BHI7
Rat protein sequence database
Cellular localization
Endoplasmic reticulum membrane ; Multi-pass membrane protein . Cell projection, dendrite . In Purkinje cells, the protein localizes to the soma and proximal portion of the dendritic tree. .
Tissue expression
Ubiquitous. Highly expressed in the adrenal gland and testis. Weakly expressed in prostate, lung and brain. Expressed in the cerebellum.
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