Immunogen
The antiserum was produced against synthesized peptide derived from human Cytochrome P450 4Z1. AA range:71-120
Specificity
CYP4Z1 Polyclonal Antibody detects endogenous levels of CYP4Z1 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
CYP4Z1 encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. CYP4Z1 is part of a cluster of cytochrome P450 genes on chromosome 1p33.
Function
oxidation reduction,
Protein name
Cytochrome P450 4Z1
Other name
CYP4Z1; Cytochrome P450 4Z1; CYPIVZ1
Human protein sequence Database
Q86W10
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Endoplasmic reticulum membrane ; Single-pass type II membrane protein . Microsome membrane ; Single-pass type II membrane protein .
Tissue expression
Preferentially detected in breast carcinoma tissue and mammary gland, whereas only marginal expression is found in all other tested tissues.
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