Molecular weight (DA)
50kD
Immunogen
The antiserum was produced against synthesized peptide derived from human Cytochrome P450 3A7. AA range:231-280
Specificity
CYP3A7 Polyclonal Antibody detects endogenous levels of CYP3A7 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the cytochrome P450 superfamily of enzymes, which participate in drug metabolism and the synthesis of cholesterol, steroids and other lipids. This enzyme hydroxylates testosterone and dehydroepiandrosterone 3-sulphate, which is involved in the formation of estriol during pregnancy. This gene is part of a cluster of related genes on chromosome 7q21.1. Naturally-occurring readthrough transcription occurs between this gene and the downstream CYP3A51P pseudogene and is represented by GeneID:100861540. [provided by RefSeq, Jan 2015],
Function
catalytic activity:RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O.,cofactor:Heme group.,function:Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.,induction:P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.,online information:CYP3A7 alleles,similarity:Belongs to the cytochrome P450 family.,
Protein name
Cytochrome P450 3A7
Other name
CYP3A7; Cytochrome P450 3A7; CYPIIIA7; Cytochrome P450-HFLA
Fields
>>Steroid hormone biosynthesis;>>Retinol metabolism;>>Metabolic pathways;>>Chemical carcinogenesis - DNA adducts
Human protein sequence Database
P24462
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane ; Peripheral membrane protein.
Tissue expression
Expressed in fetal liver (at protein level).
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