Molecular weight (DA)
58kD
Immunogen
The antiserum was produced against synthesized peptide derived from human Cytochrome P450 2J2. AA range:231-280
Specificity
CYP2J2 Polyclonal Antibody detects endogenous levels of CYP2J2 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is thought to be the predominant enzyme responsible for epoxidation of endogenous arachidonic acid in cardiac tissue. Multiple transcript variants have been found for this gene. [provided by RefSeq, Jan 2016],
Function
catalytic activity:RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O.,cofactor:Heme group.,function:This enzyme metabolizes arachidonic acid predominantly via a NADPH-dependent olefin epoxidation to all four regioisomeric cis-epoxyeicosatrienoic acids. One of the predominant enzymes responsible for the epoxidation of endogenous cardiac arachidonic acid pools.,online information:CYP2J2 alleles,similarity:Belongs to the cytochrome P450 family.,tissue specificity:Highly expressed in heart, present at lower levels in liver, ileum, jejunum, colon, and kidney.,
Protein name
Cytochrome P450 2J2
Other name
CYP2J2; Cytochrome P450 2J2; Arachidonic acid epoxygenase; CYPIIJ2
Fields
>>Arachidonic acid metabolism;>>Linoleic acid metabolism;>>Metabolic pathways;>>Serotonergic synapse;>>Inflammatory mediator regulation of TRP channels;>>Ovarian steroidogenesis;>>Lipid and atherosclerosis
Human protein sequence Database
P51589
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane ; Peripheral membrane protein.
Tissue expression
Highly expressed in heart, present at lower levels in liver, kidney and skeletal muscle (at protein level).
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