Molecular weight (DA)
72kD
Immunogen
Synthesized peptide derived from CROT . at AA range: 190-270
Specificity
CROT Polyclonal Antibody detects endogenous levels of CROT protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
IHC: 1/100 - 1/300. ELISA: 1/40000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the carnitine/choline acetyltransferase family. The encoded protein converts 4,8-dimethylnonanoyl-CoA to its corresponding carnitine ester. This transesterification occurs in the peroxisome and is necessary for transport of medium- and long- chain acyl-CoA molecules out of the peroxisome to the cytosol and mitochondria. The protein thus plays a role in lipid metabolism and fatty acid beta-oxidation. Alternatively spliced transcript variants have been described.[provided by RefSeq, Jan 2009],
Function
catalytic activity:Octanoyl-CoA + L-carnitine = CoA + L-octanoylcarnitine.,function:Beta-oxidation of fatty acids. The highest activity concerns the C6 to C10 chain length substrate. Converts the end product of pristanic acid beta oxidation, 4,8-dimethylnonanoyl-CoA, to its corresponding carnitine ester.,pathway:Lipid metabolism; fatty acid beta-oxidation.,similarity:Belongs to the carnitine/choline acetyltransferase family.,subunit:Monomer.,
Protein name
Peroxisomal carnitine O-octanoyltransferase
Other name
CROT; COT; Peroxisomal carnitine O-octanoyltransferase; COT
Human protein sequence Database
Q9UKG9
Mouse protein sequence database
Q9DC50
Rat protein sequence database
P11466
Cellular localization
Peroxisome .
Tissue expression
Brain,Skin,
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