Immunogen
The antiserum was produced against synthesized peptide derived from human COX19. AA range:10-59
Specificity
COX19 Polyclonal Antibody detects endogenous levels of COX19 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
IHC: 1/100 - 1/300. ELISA: 1/20000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
COX19 encodes a cytochrome c oxidase (COX)-assembly protein. The S. cerevisiae Cox19 protein may play a role in metal transport to the mitochondrial intermembrane space and assembly of complex IV of the mitochondrial respiratory chain (Sacconi et al., 2005 [PubMed 16212937]).[supplied by OMIM, Mar 2008],
Function
function:May be required for the assembly of mitochondrial cytochrome c oxidase.,similarity:Belongs to the COX19 family.,similarity:Contains 1 CHCH domain.,tissue specificity:Ubiquitously expressed. Highly expressed in skeletal muscle.,
Protein name
Cytochrome c oxidase assembly protein COX19
Other name
COX19; Cytochrome c oxidase assembly protein COX19; hCOX19
Human protein sequence Database
Q49B96
Mouse protein sequence database
Q8K0C8
Rat protein sequence database
Cellular localization
Cytoplasm, cytosol . Mitochondrion intermembrane space . Mitochondrion . Partitions between mitochondria and the cytosol in a copper-dependent manner. Enriched in the cytosol when intracellular copper concentrations are elevated. .
Tissue expression
Ubiquitously expressed. Highly expressed in skeletal muscle.
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