Molecular weight (DA)
31kD
Immunogen
The antiserum was produced against synthesized peptide derived from human CBR3. AA range:151-200
Specificity
Carbonyl Reductase 3 Polyclonal Antibody detects endogenous levels of Carbonyl Reductase 3 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/40000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
Carbonyl reductase 3 catalyzes the reduction of a large number of biologically and pharmacologically active carbonyl compounds to their corresponding alcohols. The enzyme is classified as a monomeric NADPH-dependent oxidoreductase. CBR3 contains three exons spanning 11.2 kilobases and is closely linked to another carbonyl reductase gene - CBR1. [provided by RefSeq, Jul 2008],
Function
catalytic activity:R-CHOH-R' + NADP(+) = R-CO-R' + NADPH.,similarity:Belongs to the short-chain dehydrogenases/reductases (SDR) family.,
Protein name
Carbonyl reductase [NADPH] 3
Abbreviation
Carbonyl Reductase 3
Other name
CBR3; Carbonyl reductase [NADPH] 3; NADPH-dependent carbonyl reductase 3
Fields
>>Arachidonic acid metabolism;>>Metabolism of xenobiotics by cytochrome P450;>>Metabolic pathways
Human protein sequence Database
O75828
Mouse protein sequence database
Q8K354
Rat protein sequence database
Cellular localization
Cytoplasm .
Tissue expression
Detected in ovary, pancreas, intestine, colon, kidney, brain, thymus, lung, heart, liver, spleen, leukocyte, prostate and testis.
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