Molecular weight (DA)
75kD
Immunogen
The antiserum was produced against synthesized peptide derived from human CAPN9. AA range:481-530
Specificity
Calpain 9 Polyclonal Antibody detects endogenous levels of Calpain 9 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/5000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. The protein encoded by this gene is expressed predominantly in stomach and small intestine and may have specialized functions in the digestive tract. This gene is thought to be associated with gastric cancer. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
Function
catalytic activity:Broad endopeptidase specificity.,function:Calcium-regulated non-lysosomal thiol-protease.,induction:Down-regulated in gastric cancer tissue and in gastric cell lines of differentiated and poorly differentiated types.,similarity:Belongs to the peptidase C2 family.,similarity:Contains 1 calpain catalytic domain.,similarity:Contains 3 EF-hand domains.,tissue specificity:Expressed predominantly in stomach.,
Other name
CAPN9; NCL4; Calpain-9; Digestive tract-specific calpain; New calpain 4; nCL-4; Protein CG36
Human protein sequence Database
O14815
Mouse protein sequence database
Q9D805
Rat protein sequence database
Cellular localization
intracellular,cytoplasm,
Tissue expression
Expressed predominantly in stomach.
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