Molecular weight (DA)
45kD
Immunogen
The antiserum was produced against synthesized peptide derived from human ABHD12. AA range:231-280
Specificity
ABHD12 Polyclonal Antibody detects endogenous levels of ABHD12 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/40000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes an enzyme that catalyzes the hydrolysis of 2-arachidonoyl glycerol (2-AG), the main endocannabinoid lipid transmitter that acts on cannabinoid receptors, CB1 and CB2. The endocannabinoid system is involved in a wide range of physiological processes, including neurotransmission, mood, appetite, pain appreciation, addiction behavior, and inflammation. Mutations in this gene are associated with the neurodegenerative disease, PHARC (polyneuropathy, hearing loss, ataxia, retinitis pigmentosa, and cataract), resulting from an inborn error of endocannabinoid metabolism. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Jan 2011],
Function
catalytic activity:Hydrolyzes glycerol monoesters of long-chain fatty acids.,function:Has 2-arachidonoylglycerol hydrolase activity (By similarity). May be a regulator of endocannabinoid signaling pathways.,PTM:Glycosylated.,similarity:Belongs to the serine esterase family.,
Protein name
Monoacylglycerol lipase ABHD12
Other name
ABHD12; C20orf22; Monoacylglycerol lipase ABHD12; 2-arachidonoylglycerol hydrolase; Abhydrolase domain-containing protein 12
Human protein sequence Database
Q8N2K0
Mouse protein sequence database
Q99LR1
Rat protein sequence database
Q6AYT7
Cellular localization
Endoplasmic reticulum membrane ; Single-pass membrane protein .
Tissue expression
Cerebellum,Kidney,Ovarian carcinoma,Pancreas,Testis,
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