Molecular weight (DA)
84kD
Immunogen
Synthesized phospho-peptide around the phosphorylation site of human Glycogen Synthase 1 (phospho Ser641)
Specificity
Phospho-Glycogen Synthase 1 (S641) Polyclonal Antibody detects endogenous levels of Glycogen Synthase 1 protein only when phosphorylated at S641.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene catalyzes the addition of glucose monomers to the growing glycogen molecule through the formation of alpha-1,4-glycoside linkages. Mutations in this gene are associated with muscle glycogen storage disease. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009],
Function
catalytic activity:UDP-glucose ((1->4)-alpha-D-glucosyl)(n) = UDP + ((1->4)-alpha-D-glucosyl)(n+1).,disease:Defects in GYS1 are the cause of muscle glycogen storage disease type 0 (GSD0b) [MIM:611556]; also called muscle glycogen synthase deficiency. GSD0 is a metabolic disorder characterized by fasting hypoglycemia presenting in infancy or early childhood. The role of muscle glycogen is to provide critical energy during bursts of activity and sustained muscle work.,enzyme regulation:Allosteric activation by glucose-6-phosphate. Phosphorylation reduces the activity towards UDP-glucose. When in the non-phosphorylated state, glycogen synthase does not require glucose-6-phosphate as an allosteric activator; when phosphorylated it does.,function:Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.,pathway:Glycan biosynthesis; glycogen biosynthesis.,similar
Protein name
Glycogen [starch] synthase muscle
Abbreviation
Glycogen Synthase 1
Other name
GYS1; GYS; Glycogen [starch] synthase; muscle
Fields
>>Starch and sucrose metabolism;>>Metabolic pathways;>>PI3K-Akt signaling pathway;>>AMPK signaling pathway;>>Insulin signaling pathway;>>Glucagon signaling pathway;>>Insulin resistance;>>Diabetic cardiomyopathy
Human protein sequence Database
P13807
Mouse protein sequence database
Q9Z1E4
Rat protein sequence database
Cellular localization
cytosol,membrane,inclusion body,
Tissue expression
Endometrium,Heart,Kidney,Lymph,Muscle,Skin,
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