Molecular weight (DA)
105-109kD
Immunogen
Synthetic Peptide of PEPC
Specificity
The antibody detects endogenous PEPC protein.
Formulation
PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.
Dilution rate
WB: 1:2000-5000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes an aspartic proteinase that belongs to the peptidase family A1. The encoded protein is a digestive enzyme that is produced in the stomach and constitutes a major component of the gastric mucosa. This protein is also secreted into the serum. This protein is synthesized as an inactive zymogen that includes a highly basic prosegment. This enzyme is converted into its active mature form at low pH by sequential cleavage of the prosegment that is carried out by the enzyme itself. Polymorphisms in this gene are associated with susceptibility to gastric cancers. Serum levels of this enzyme are used as a biomarker for certain gastric diseases including Helicobacter pylori related gastritis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 1. [provided by RefSeq, Oct 2009],
Function
catalytic activity:More restricted specificity than pepsin A, but shows preferential cleavage at Tyr-|-Xaa bonds. High activity on hemoglobin.,function:Hydrolyzes a variety of proteins.,similarity:Belongs to the peptidase A1 family.,
Other name
PGC; Gastricsin; Pepsinogen C
Human protein sequence Database
Mouse protein sequence database
Rat protein sequence database
Cellular localization
extracellular space,extracellular exosome,
Tissue expression
Brain,Liver,Placenta,Stomach,
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