Molecular weight (DA)
37kD
Immunogen
The antiserum was produced against synthesized peptide derived from human CATL2. AA range:95-144
Specificity
Cleaved-Cathepsin L2 (L114) Polyclonal Antibody detects endogenous levels of fragment of activated Cathepsin L2 protein resulting from cleavage adjacent to L114.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that may play an important role in corneal physiology. This gene is expressed in colorectal and breast carcinomas but not in normal colon, mammary gland, or peritumoral tissues, suggesting a possible role for this gene in tumor processes. Alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2011],
Function
catalytic activity:The recombinant enzyme hydrolyzes proteins (serum albumin, collagen) and synthetic substrates (Z-Phe-Arg-NHMec > Z-Leu-Arg-NHMec > Z-Val-Arg-NHMec).,function:Cysteine protease. May have an important role in corneal physiology.,similarity:Belongs to the peptidase C1 family.,tissue specificity:Predominantly expressed in the thymus and testis. Also expressed in corneal epithelium, and to a lesser extent in conjuctival epithelium and skin.,
Protein name
Cathepsin L2
Abbreviation
Cathepsin L2
Other name
CTSL2; CATL2; CTSU; CTSV; Cathepsin L2; Cathepsin U; Cathepsin V
Fields
>>Lysosome;>>Apoptosis
Human protein sequence Database
O60911
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Lysosome .
Tissue expression
Predominantly expressed in the thymus and testis. Also expressed in corneal epithelium, and to a lesser extent in conjunctival epithelium and skin.
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