Molecular weight (DA)
40kD
Immunogen
Synthesized peptide derived from Cathepsin H . at AA range: 70-150
Specificity
Cathepsin H Polyclonal Antibody detects endogenous levels of Cathepsin H protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. ELISA: 1/20000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is a lysosomal cysteine proteinase important in the overall degradation of lysosomal proteins. It is composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. The encoded protein, which belongs to the peptidase C1 protein family, can act both as an aminopeptidase and as an endopeptidase. Increased expression of this gene has been correlated with malignant progression of prostate tumors. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016],
Function
catalytic activity:Hydrolysis of proteins, acting as an aminopeptidase (notably, cleaving Arg-|-Xaa bonds) as well as an endopeptidase.,function:Important for the overall degradation of proteins in lysosomes.,similarity:Belongs to the peptidase C1 family.,subunit:Composed of a mini chain and a large chain. The large chain may be split into heavy and light chain. All chains are held together by disulfide bonds.,
Protein name
Pro-cathepsin H
Other name
CTSH; CPSB; Pro-cathepsin H
Fields
>>Lysosome;>>Apoptosis
Human protein sequence Database
P09668
Mouse protein sequence database
P49935
Rat protein sequence database
Cellular localization
Lysosome.
Tissue expression
Cartilage,Eye,Kidney,Liver,Lung,Salivary gland,
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