Molecular weight (DA)
115kD
Immunogen
Synthesized peptide derived from Topo IIIα . at AA range: 350-430
Specificity
Topo IIIα Polyclonal Antibody detects endogenous levels of Topo IIIα protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus reducing the number of supercoils and altering the topology of DNA. This enzyme forms a complex with BLM which functions in the regulation of recombination in somatic cells. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016],
Function
catalytic activity:ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.,function:Reduces the number of supercoils in a highly negatively supercoiled DNA. Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells.,similarity:Belongs to the prokaryotic type I/III topoisomerase family.,subunit:Directly interacts with BLM and RMI1. Component of the RMI complex, containing at least TOP3A, RMI1 and RMI2. The RMI complex interacts with BLM.,tissue specificity:High expression is found in testis, heart, skeletal muscle and pancreas.,
Protein name
DNA topoisomerase 3-alpha
Other name
TOP3A; TOP3; DNA topoisomerase 3-alpha; DNA topoisomerase III alpha
Fields
>>Homologous recombination;>>Fanconi anemia pathway
Human protein sequence Database
Q13472
Mouse protein sequence database
O70157
Rat protein sequence database
Cellular localization
Mitochondrion matrix .
Tissue expression
High expression is found in testis, heart, skeletal muscle and pancreas.
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