Molecular weight (DA)
97kD
Immunogen
The antiserum was produced against synthesized peptide derived from the Internal region of human MACC1. AA range:411-460
Specificity
MACC1 Polyclonal Antibody detects endogenous levels of MACC1 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
MACC1 is a key regulator of the hepatocyte growth factor (HGF; MIM 142409)-HGF receptor (HGFR, or MET; MIM 164860) pathway, which is involved in cellular growth, epithelial-mesenchymal transition, angiogenesis, cell motility, invasiveness, and metastasis. Expression of MACC1 in colon cancer (MIM 114500) specimens is an independent prognostic indicator for metastasis formation and metastasis-free survival (Stein et al., 2009 [PubMed 19098908]).[supplied by OMIM, Mar 2009],
Function
function:Acts as a transcription activator for MET and as a key regulator of HGF-MET signaling. Promotes cell motility, proliferation and hepatocyte growth factor (HGF)-dependent scattering in vitro and tumor growth and metastasis in vivo.,similarity:Contains 1 SH3 domain.,subcellular location:Mainly found in the cytoplasm in non-metastasizing tumors.,tissue specificity:Preferentially expressed in metastasizing tumors.,
Protein name
Metastasis-associated in colon cancer protein 1
Other name
MACC1; Metastasis-associated in colon cancer protein 1; SH3 domain-containing protein 7a5
Human protein sequence Database
Q6ZN28
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Cytoplasm . Nucleus . Mainly found in the cytoplasm in non-metastasizing tumors.
Tissue expression
Preferentially expressed in metastasizing tumors.
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