Molecular weight (DA)
160kD
Immunogen
The antiserum was produced against synthesized peptide derived from human ZNF592. AA range:961-1010
Specificity
ZNF592 Polyclonal Antibody detects endogenous levels of ZNF592 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/40000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
zinc finger protein 592(ZNF592) Homo sapiens This gene is thought to play a role in a complex developmental pathway and the regulation of genes involved in cerebellar development. Mutations in this gene have been associated with autosomal recessive spinocerebellar ataxia. [provided by RefSeq, Jan 2011],
Function
function:May be involved in transcriptional regulation.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the krueppel C2H2-type zinc-finger protein family.,similarity:Contains 13 C2H2-type zinc fingers.,
Protein name
Zinc finger protein 592
Other name
ZNF592; KIAA0211; Zinc finger protein 592
Human protein sequence Database
Q92610
Mouse protein sequence database
Q8BHZ4
Rat protein sequence database
Cellular localization
Nucleus .
Tissue expression
Widely expressed, with highest levels in skeletal muscle. Expressed throughout the central nervous system, including in the cerebellum and cerebellar vermis, with higher expression in the substantia nigra. Widely expressed in fetal tissues.
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