Molecular weight (DA)
80kD
Immunogen
Synthesized peptide derived from XE7 . at AA range: 590-670
Specificity
XE7 Polyclonal Antibody detects endogenous levels of XE7 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
A-kinase anchoring protein 17A(AKAP17A) Homo sapiens This locus encodes a protein kinase A anchoring protein. The encoded protein is part of the spliceosome complex and is involved in the regulation of alternate splicing in some mRNA precursors. Alternatively spliced transcript variants have been identified for this gene.[provided by RefSeq, Sep 2010],
Function
caution:Was originally (PubMed:1438229) thought to be a cell surface protein involved in B-cell activation.,function:Splice factor regulating alternative splice site selection for certain mRNA precursors.,miscellaneous:The gene encoding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes.,similarity:Contains 1 RRM (RNA recognition motif) domain.,subunit:Monomer. Component of the spliceosome. Interacts with ZRANB2 and SFRS1/ASF through its Arg/Ser-rich domain.,tissue specificity:Widely expressed. Found in heart, brain, lung, liver, skeletal muscle, kidney and pancreas. Expressed in activated B-cells and placenta.,
Protein name
A-kinase anchor protein 17A
Other name
AKAP17A; CXYorf3; DXYS155E; SFRS17A; XE7; A-kinase anchor protein 17A; AKAP-17A; 721P; B-lymphocyte antigen; Protein XE7; Protein kinase A-anchoring protein 17A; PRKA17A; Splicing factor; arginine/serine-rich 17A
Human protein sequence Database
Q02040
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Nucleus speckle .
Tissue expression
Widely expressed. Found in heart, brain, lung, liver, skeletal muscle, kidney and pancreas. Expressed in activated B-cells and placenta. Expressed in all cell lines tested including Jurkat-TAg, U-937 and HEK293 cells.
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