Molecular weight (DA)
89kD
Immunogen
Synthesized peptide derived from UBF . at AA range: 420-500
Specificity
UBF Polyclonal Antibody detects endogenous levels of UBF protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the HMG-box DNA-binding protein family. The encoded protein plays a critical role in ribosomal RNA transcription as a key component of the pre-initiation complex, mediating the recruitment of RNA polymerase I to rDNA promoter regions. The encoded protein may also play important roles in chromatin remodeling and pre-rRNA processing, and its activity is regulated by both phosphorylation and acetylation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Pseudogenes of this gene are located on the short arm of chromosomes 3, 11 and X and the long arm of chromosome 11. [provided by RefSeq, Aug 2011],
Function
function:Recognizes the ribosomal RNA gene promoter and activates transcription mediated by RNA polymerase I through cooperative interactions with the species-specific factor SL1. It binds specifically to the upstream control element.,PTM:Phosphorylated and activated by PIK3CA.,similarity:Contains 6 HMG box DNA-binding domains.,subunit:Homodimer. Binds to IRS1 and PIK3CA.,
Protein name
Nucleolar transcription factor 1
Other name
UBTF; UBF; UBF1; Nucleolar transcription factor 1; Autoantigen NOR-90; Upstream-binding factor 1; UBF-1
Human protein sequence Database
P17480
Mouse protein sequence database
P25976
Rat protein sequence database
P25977
Cellular localization
Nucleus, nucleolus .
Tissue expression
Lymph,Placenta,Testis,
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