Immunogen
Synthesized peptide derived from SRp55 . at AA range: 30-110
Specificity
SRp55 Polyclonal Antibody detects endogenous levels of SRp55 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
IHC: 1/100 - 1/300. ELISA: 1/20000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is involved in mRNA splicing and may play a role in the determination of alternative splicing. The encoded nuclear protein belongs to the splicing factor SR family and has been shown to bind with and modulate another member of the family, SFRS12. Alternative splicing results in multiple transcript variants. In addition, two pseudogenes, one on chromosome 17 and the other on the X chromosome, have been found for this gene.[provided by RefSeq, Sep 2010],
Function
function:Plays a role in constitutive splicing and can modulate the selection of alternative splice sites.,PTM:Extensively phosphorylated on serine residues in the RS domain.,similarity:Belongs to the splicing factor SR family.,similarity:Contains 2 RRM (RNA recognition motif) domains.,subunit:Binds SFRS12.,
Protein name
Serine/arginine-rich splicing factor 6
Other name
SRSF6; SFRS6; SRP55; Serine/arginine-rich splicing factor 6; Pre-mRNA-splicing factor SRP55; Splicing factor; arginine/serine-rich 6
Fields
>>Spliceosome;>>Herpes simplex virus 1 infection
Human protein sequence Database
Q13247
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Nucleus . Nucleus speckle .
Tissue expression
Brain,Colon,Epithelium,Placenta,
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