Molecular weight (DA)
64kD
Immunogen
The antiserum was produced against synthesized peptide derived from human SP2. AA range:471-520
Specificity
Sp2 Polyclonal Antibody detects endogenous levels of Sp2 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/20000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the Sp subfamily of Sp/XKLF transcription factors. Sp family proteins are sequence-specific DNA-binding proteins characterized by an amino-terminal trans-activation domain and three carboxy-terminal zinc finger motifs. This protein contains the least conserved DNA-binding domain within the Sp subfamily of proteins, and its DNA sequence specificity differs from the other Sp proteins. It localizes primarily within subnuclear foci associated with the nuclear matrix, and can activate or in some cases repress expression from different promoters. [provided by RefSeq, Jul 2008],
Function
function:Binds to GC box promoters elements and selectively activates mRNA synthesis from genes that contain functional recognition sites.,similarity:Belongs to the Sp1 C2H2-type zinc-finger protein family.,similarity:Contains 3 C2H2-type zinc fingers.,
Protein name
Transcription factor Sp2
Other name
SP2; KIAA0048; Transcription factor Sp2
Human protein sequence Database
Q02086
Mouse protein sequence database
Q9D2H6
Rat protein sequence database
Cellular localization
Nucleus.
Tissue expression
Bone marrow,Brain,Lung,Lymph,Spleen,
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