Molecular weight (DA)
180kD
Immunogen
The antiserum was produced against synthesized peptide derived from human RREB1. AA range:560-609
Specificity
RREB1 Polyclonal Antibody detects endogenous levels of RREB1 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/20000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
ras responsive element binding protein 1(RREB1) Homo sapiens The protein encoded by this gene is a zinc finger transcription factor that binds to RAS-responsive elements (RREs) of gene promoters. It has been shown that the calcitonin gene promoter contains an RRE and that the encoded protein binds there and increases expression of calcitonin, which may be involved in Ras/Raf-mediated cell differentiation. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Dec 2009],
Function
function:Transcription factor that binds specifically to the RAS-responsive elements (RRE) of gene promoters. May be involved in Ras/Raf-mediated cell differentiation by enhancing calcitonin expression. Represses the angiotensinogen gene. Negatively regulates the transcriptional activity of AR. Potentiates the transcriptional activity of NEUROD1.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,sequence caution:Contaminating sequence. Potential poly-A sequence.,sequence caution:Numerous sequencing errors.,sequence caution:Translation N-terminally extended.,similarity:Belongs to the krueppel C2H2-type zinc-finger protein family.,similarity:Contains 15 C2H2-type zinc fingers.,subunit:Interacts with NEUROD1 and AR.,tissue specificity:Expressed in heart, placenta, lung, liver, skeletal muscle, kidney and pancreas. Not found in the brain.,
Protein name
Ras-responsive element-binding protein 1
Other name
RREB1; FINB; Ras-responsive element-binding protein 1; RREB-1; Finger protein in nuclear bodies; Raf-responsive zinc finger protein LZ321; Zinc finger motif enhancer-binding protein 1; Zep-1
Human protein sequence Database
Q92766
Mouse protein sequence database
Q3UH06
Rat protein sequence database
Cellular localization
Nucleus speckle .
Tissue expression
Expressed in heart, placenta, lung, liver, skeletal muscle, kidney and pancreas. Not found in the brain.
Contract Us
Follow Us
Location： 
Specification
成功添加到购物车