Molecular weight (DA)
36kD
Immunogen
The antiserum was produced against synthesized peptide derived from human RNF130. AA range:231-280
Specificity
RNF130 Polyclonal Antibody detects endogenous levels of RNF130 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
ring finger protein 130(RNF130) Homo sapiens The protein encoded by this gene contains a RING finger motif and is similar to g1, a Drosophila zinc-finger protein that is expressed in mesoderm and involved in embryonic development. The expression of the mouse counterpart was found to be upregulated in myeloblastic cells following IL3 deprivation, suggesting that this gene may regulate growth factor withdrawal-induced apoptosis of myeloid precursor cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013],
Function
function:May have a role during the programmed cell death of hematopoietic cells.,similarity:Contains 1 PA (protease associated) domain.,similarity:Contains 1 RING-type zinc finger.,
Protein name
E3 ubiquitin-protein ligase RNF130
Other name
RNF130; E3 ubiquitin-protein ligase RNF130; Goliath homolog; H-Goliath; RING finger protein 130
Human protein sequence Database
Q86XS8
Mouse protein sequence database
Q8VEM1
Rat protein sequence database
Q6Y290
Cellular localization
Membrane ; Single-pass type I membrane protein . Cytoplasm .
Tissue expression
Ubiquitously expressed. Highly expressed in leukocytes. Not expressed in erythroblasts.
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