Molecular weight (DA)
50kD
Immunogen
The antiserum was produced against synthesized peptide derived from human PRIM1. AA range:371-420
Specificity
PRIM1 Polyclonal Antibody detects endogenous levels of PRIM1 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/10000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The replication of DNA in eukaryotic cells is carried out by a complex chromosomal replication apparatus, in which DNA polymerase alpha and primase are two key enzymatic components. Primase, which is a heterodimer of a small subunit and a large subunit, synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication. The protein encoded by this gene is the small, 49 kDa primase subunit. [provided by RefSeq, Jul 2008],
Function
function:DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication.,miscellaneous:The bound zinc ion is not a cofactor. It is bound to a zinc knuckle motif that may be involved in sequence recognition and the binding of ssDNA.,similarity:Belongs to the eukaryotic-type primase small subunit family.,subunit:Heterodimer of a small subunit and a large subunit.,
Protein name
DNA primase small subunit
Other name
PRIM1; DNA primase small subunit; DNA primase 49 kDa subunit; p49
Human protein sequence Database
P49642
Mouse protein sequence database
P20664
Rat protein sequence database
Cellular localization
nucleoplasm,alpha DNA polymerase:primase complex,membrane,primosome complex,
Tissue expression
Bone marrow,Thymus,
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