Molecular weight (DA)
20kD
Immunogen
The antiserum was produced against synthesized peptide derived from human RPB11. AA range:10-59
Specificity
POLR2J1 Polyclonal Antibody detects endogenous levels of POLR2J1 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000;IHC-p 1:50-300
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene exists as a heterodimer with another polymerase subunit; together they form a core subassembly unit of the polymerase. Two similar genes are located nearby on chromosome 7q22.1 and a pseudogene is found on chromosome 7p13. [provided by RefSeq, Jul 2008],
Function
function:DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB11 is part of the core element with the central large cleft.,similarity:Belongs to the archaeal rpoL/eukaryotic RPB11/RPC19 RNA polymerase subunit family.,subunit:Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits. Interacts with AATF.,tissue specificity:Ubiquitously expressed. High expression was found in heart and skeletal muscle.,
Protein name
DNA-directed RNA polymerase II subunit RPB11-a
Other name
POLR2J; POLR2J1; DNA-directed RNA polymerase II subunit RPB11-a; RNA polymerase II subunit B11-a; RPB11a; DNA-directed RNA polymerase II subunit J-1; RNA polymerase II 13.3 kDa subunit
Fields
>>RNA polymerase;>>Huntington disease
Human protein sequence Database
P52435
Mouse protein sequence database
O08740
Rat protein sequence database
Cellular localization
Nucleus .
Tissue expression
Ubiquitously expressed. High expression was found in heart and skeletal muscle.
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