Immunogen
Synthesized peptide derived from Maf1 . at AA range: 110-190
Specificity
Maf1 Polyclonal Antibody detects endogenous levels of Maf1 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
IHC: 1/100 - 1/300. ELISA: 1/20000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a protein that is similar to Maf1, a Saccharomyces cerevisiae protein highly conserved in eukaryotic cells. Yeast Maf1 is a negative effector of RNA polymerase III (Pol III). It responds to changes in the cellular environment and represses pol III transcription. Biochemical studies identified the initiation factor TFIIIB as a target for Maf1-dependent repression. [provided by RefSeq, Jul 2008],
Function
function:Mediator of diverse signals that repress RNA polymerase III transcription. Inhibits the de novo assembly of TFIIIB onto DNA.,similarity:Belongs to the MAF1 family.,subunit:Interacts with BRF2.,
Protein name
Repressor of RNA polymerase III transcription MAF1 homolog
Other name
MAF1; Repressor of RNA polymerase III transcription MAF1 homolog
Human protein sequence Database
Q9H063
Mouse protein sequence database
Q9D0U6
Rat protein sequence database
Q5XIH0
Cellular localization
Nucleus . Cytoplasm .
Tissue expression
Brain,Epithelium,Lung,Uterus,
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