hnRNP M Polyclonal Antibody

Polyclonal antibody

Specification

BYab-01811

50UL $180 100UL $255
Delivery： In Stock

Product introduction Experimental scheme Citation Related products

Product introduction>

Host

Reactiveness

Use

Molecular weight (DA)

78kD

Immunogen

The antiserum was produced against synthesized peptide derived from human hnRNP M. AA range:11-60

Specificity

hnRNP M Polyclonal Antibody detects endogenous levels of hnRNP M protein.

Source

Formulation

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Dilution rate

Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/40000. Not yet tested in other applications.

Purification process (Immunogen)

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Background

This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that bind to RNAs. This protein also constitutes a monomer of the N-acetylglucosamine-specific receptor which is postulated to trigger selective recycling of immature GlcNAc-bearing thyroglobulin molecules. Alternative splicing results in multiple transcript variants. [provide

Function

alternative products:Experimental confirmation may be lacking for some isoforms,function:Pre-mRNA binding protein in vivo, binds avidly to poly(G) and poly(U) RNA homopolymers in vitro. Involved in splicing. Acts as a receptor for carcinoembryonic antigen in Kupffer cells, may initiate a series of signaling events leading to tyrosine phosphorylation of proteins and induction of IL-1 alpha, IL-6, IL-10 and tumor necrosis factor alpha cytokines.,PTM:Sumoylated.,similarity:Contains 3 RRM (RNA recognition motif) domains.,subunit:Identified in the spliceosome C complex, at least composed of AQR, ASCC3L1, C19orf29, CDC40, CDC5L, CRNKL1, DDX23, DDX41, DDX48, DDX5, DGCR14, DHX35, DHX38, DHX8, EFTUD2, FRG1, GPATC1, HNRPA1, HNRPA2B1, HNRPA3, HNRPC, HNRPF, HNRPH1, HNRPK, HNRNPM, HNRPR, HNRPU, KIAA1160, KIAA1604, LSM2, LSM3, MAGOH, MORG1, PABPC1, PLRG1, PNN, PPIE, PPIL1, PPIL3, PPWD1, PRPF19, PRPF4B

Gene Name

HNRNPM

Protein name

Heterogeneous nuclear ribonucleoprotein M

Abbreviation

hnRNP M

Other name

HNRNPM; HNRPM; NAGR1; Heterogeneous nuclear ribonucleoprotein M; hnRNP M

Fields

>>Spliceosome

Human gene ID

4670

Human protein sequence Database

P52272

Mouse gene ID

76936

Mouse protein sequence database

Q9D0E1

Rat gene ID

116655

Rat protein sequence database

Q62826

Cellular localization

Nucleus, nucleolus .

Tissue expression

Brain,Cervix carcinoma,Duodenum,Epithelium,Lymph,Placenta,T

Storage

-20°C/1 year

Experimental scheme>

Procedure

hnRNP M Polyclonal Antibody

BYab-01811

Product introduction>

Host

Reactiveness

Use

Molecular weight (DA)

Immunogen

Specificity

Source

Formulation

Dilution rate

Purification process (Immunogen)

Concentration

Background

Function

Gene Name

Protein name

Abbreviation

Other name

Fields

Human gene ID

Human protein sequence Database

Mouse gene ID

Mouse protein sequence database

Rat gene ID

Rat protein sequence database

Cellular localization

Tissue expression

Storage

Experimental scheme>

Citation(0)>

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hnRNP M Polyclonal Antibody

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