Molecular weight (DA)
56kD
Immunogen
The antiserum was produced against synthesized peptide derived from human IKZF2. AA range:331-380
Specificity
Helios Polyclonal Antibody detects endogenous levels of Helios protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This protein forms homo- or hetero-dimers with other Ikaros family members, and is thought to function predominantly in early hematopoietic development. Multiple transcript variants encoding different isoforms have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008],
Function
function:Associates with Ikaros at centromeric heterochromatin.,similarity:Belongs to the Ikaros C2H2-type zinc-finger protein family.,similarity:Contains 6 C2H2-type zinc fingers.,subunit:Interacts with IKZF4 AND IKZF5.,
Protein name
Zinc finger protein Helios
Other name
IKZF2; HELIOS; ZNFN1A2; Zinc finger protein Helios; Ikaros family zinc finger protein 2
Human protein sequence Database
Q9UKS7
Mouse protein sequence database
P81183
Rat protein sequence database
Cellular localization
Nucleus .
Tissue expression
Epithelium,Testis,
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