Molecular weight (DA)
73kD
Immunogen
Synthesized peptide derived from the N-terminal region of human FBP2.
Specificity
FBP2 Polyclonal Antibody detects endogenous levels of FBP2 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The KHSRP gene encodes a multifunctional RNA-binding protein implicated in a variety of cellular processes, including transcription, alternative pre-mRNA splicing, and mRNA localization (Min et al., 1997 [PubMed 9136930]; Gherzi et al., 2004 [PubMed 15175153]).[supplied by OMIM, Apr 2010],
Function
function:Binds to the dendritic targeting element and may play a role in mRNA trafficking (By similarity). Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly by recruiting degradation machinery to ARE-containing mRNAs.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the KHSRP family.,similarity:Contains 4 KH domains.,subcellular location:A small proportion is also found in the cytoplasm of neuronal cell bodies and dendrites.,subunit:Part of a ternary complex containing FUBP2, PTBP1, PTBP2 and
Protein name
Far upstream element-binding protein 2
Other name
KHSRP; FUBP2; Far upstream element-binding protein 2; FUSE-binding protein 2; KH type-splicing regulatory protein; KSRP; p75
Human protein sequence Database
Q92945
Mouse protein sequence database
Q3U0V1
Rat protein sequence database
Q99PF5
Cellular localization
Nucleus . Cytoplasm . A small proportion is also found in the cytoplasm of neuronal cell bodies and dendrites. .
Tissue expression
Detected in neural and non-neural cell lines.
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