Molecular weight (DA)
70kD
Immunogen
The antiserum was produced against synthesized peptide derived from human ELF4. AA range:178-227
Specificity
Elf-4 Polyclonal Antibody detects endogenous levels of Elf-4 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is a transcriptional activator that binds and activates the promoters of the CSF2, IL3, IL8, and PRF1 genes. The encoded protein is involved in natural killer cell development and function, innate immunity, and induction of cell cycle arrest in naive CD8+ cells. Two transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Jan 2010],
Function
function:Transcriptional activator that binds to DNA sequences containing the consensus 5'-WGGA-3'. Transactivates promoters of the hematopoietic growth factor genes CSF2, IL3, IL8, and of the bovine lysozyme gene. Acts synergistically with RUNX1 to transactivate the IL3 promoter. Also transactivates the PRF1 promoter in natural killer (NK) cells. Plays a role in the development and function of NK and NK T-cells and in innate immunity.,induction:By ponisterone A in erythroleukemia cells.,similarity:Belongs to the ETS family.,similarity:Contains 1 ETS DNA-binding domain.,subcellular location:Accumulation into PML nuclear bodies is mediated by PML.,subunit:Interacts via an N-terminal region with the RUNX1 Runt domain. Interacts via its C-terminus with PML; this interaction enhances ELF4 transactivation of the bovine lysozyme gene.,tissue specificity:Abundantly expressed in the placenta and
Protein name
ETS-related transcription factor Elf-4
Other name
ELF4; ELFR; MEF; ETS-related transcription factor Elf-4; E74-like factor 4; Myeloid Elf-1-like factor
Human protein sequence Database
Q99607
Mouse protein sequence database
Q9Z2U4
Rat protein sequence database
Cellular localization
Nucleus, PML body . Accumulation into PML nuclear bodies is mediated by PML.
Tissue expression
Abundantly expressed in the placenta and in a variety of myeloid leukemia cell lines. Moderate levels of expression in heart, lung, spleen, thymus, peripheral blood lymphocytes, ovary and colon. Lower levels of expression in Jurkat T-cells and other T-cell lines and no expression in brain.
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