Molecular weight (DA)
28kD
Immunogen
The antiserum was produced against synthesized peptide derived from human CEBPD/E. AA range:171-220
Specificity
C/EBP δ/ε Polyclonal Antibody detects endogenous levels of C/EBP δ/ε protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related protein CEBP-alpha. The encoded protein is important in the regulation of genes involved in immune and inflammatory responses, and may be involved in the regulation of genes associated with activation and/or differentiation of macrophages. The cytogenetic location of this locus has been reported as both 8p11 and 8q11. [provided by RefSeq, Sep 2010],
Function
function:C/EBP is a DNA-binding protein that recognizes two different motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers. Important transcriptional activator in the regulation of genes involved in immune and inflammatory responses, may play an important role in the regulation of the several genes associated with activation and/or differentiation of macrophages.,similarity:Belongs to the bZIP family. C/EBP subfamily.,similarity:Contains 1 bZIP domain.,subunit:Binds DNA as a dimer and can form stable heterodimers with C/EBP alpha. Interacts with SPI1/PU.1.,
Protein name
CCAAT/enhancer-binding protein delta/epsilon
Other name
CEBPD; CCAAT/enhancer-binding protein delta; C/EBP delta; Nuclear factor NF-IL6-beta; NF-IL6-beta; CEBPE; CCAAT/enhancer-binding protein epsilon; C/EBP epsilon
Human protein sequence Database
P49716/Q15744
Mouse gene ID
12609/110794
Mouse protein sequence database
Rat protein sequence database
Q03484/P56261
Cellular localization
Nucleus .
Tissue expression
Cerebellum,Placenta,
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