Molecular weight (DA)
55kD
Immunogen
Recombinant Protein of LDHD
Specificity
The antibody detects endogenous LDHD protein.
Formulation
PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.
Dilution rate
WB: 1:1000-5000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. The similar protein in yeast has both D-lactate and D-glycerate dehydrogenase activities. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008],
Function
catalytic activity:(R)-lactate + 2 ferricytochrome c = pyruvate + 2 ferrocytochrome c.,cofactor:FAD.,similarity:Belongs to the FAD-binding oxidoreductase/transferase type 4 family.,similarity:Contains 1 FAD-binding PCMH-type domain.,subunit:Interacts with CSRP3.,tissue specificity:Expressed moderately in heart and liver and at lower levels in skeletal muscle and kidney.,
Protein name
Probable D-lactate dehydrogenase, mitochondrial
Other name
Probable D-lactate dehydrogenase, mitochondrial (DLD) (Lactate dehydrogenase D) (EC 1.1.2.4)
Fields
>>Pyruvate metabolism;>>Metabolic pathways
Human protein sequence Database
Q86WU2
Mouse protein sequence database
Q7TNG8
Rat protein sequence database
Cellular localization
Mitochondrion .
Tissue expression
Expressed moderately in heart and liver and at lower levels in skeletal muscle and kidney.
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