Molecular weight (DA)
25kD
Immunogen
The antiserum was produced against synthesized peptide derived from the C-terminal region of human SNAP23. AA range:151-200
Specificity
SNAP 23 Polyclonal Antibody detects endogenous levels of SNAP 23 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC-p: 1:100-300 ELISA: 1/20000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
Specificity of vesicular transport is regulated, in part, by the interaction of a vesicle-associated membrane protein termed synaptobrevin/VAMP with a target compartment membrane protein termed syntaxin. These proteins, together with SNAP25 (synaptosome-associated protein of 25 kDa), form a complex which serves as a binding site for the general membrane fusion machinery. Synaptobrevin/VAMP and syntaxin are believed to be involved in vesicular transport in most, if not all cells, while SNAP25 is present almost exclusively in the brain, suggesting that a ubiquitously expressed homolog of SNAP25 exists to facilitate transport vesicle/target membrane fusion in other tissues. The protein encoded by this gene is structurally and functionally similar to SNAP25 and binds tightly to multiple syntaxins and synaptobrevins/VAMPs. It is an essential component of the high affinity receptor for the
Function
function:Essential component of the high affinity receptor for the general membrane fusion machinery and an important regulator of transport vesicle docking and fusion.,similarity:Belongs to the SNAP-25 family.,similarity:Contains 2 t-SNARE coiled-coil homology domains.,subcellular location:Mainly localized to the plasma membrane.,subunit:Binds simultaneously to SNAP25BP and SYN4. Found in a complex with VAMP8 and STX4 in pancreas (By similarity). Binds tightly to multiple syntaxins and synaptobrevins/VAMPs. Found in a complex with VAMP8 and STX1A.,tissue specificity:Ubiquitous. Highest levels where found in placenta.,
Protein name
Synaptosomal-associated protein 23
Other name
SNAP23; Synaptosomal-associated protein 23; SNAP-23; Vesicle-membrane fusion protein SNAP-23
Fields
>>SNARE interactions in vesicular transport;>>Platelet activation
Human protein sequence Database
O00161
Mouse protein sequence database
O09044
Rat protein sequence database
Cellular localization
Cell membrane; Peripheral membrane protein. Cell membrane; Lipid-anchor. Cell junction, synapse, synaptosome. Mainly localized to the plasma membrane.
Tissue expression
Ubiquitous. Highest levels where found in placenta.
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