Molecular weight (DA)
48kD
Immunogen
The antiserum was produced against synthesized peptide derived from human RAD23A. AA range:91-140
Specificity
Rad23A Polyclonal Antibody detects endogenous levels of Rad23A protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000;IHC-p 1:50-300
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is one of two human homologs of Saccharomyces cerevisiae Rad23, a protein involved in nucleotide excision repair. Proteins in this family have a modular domain structure consisting of an ubiquitin-like domain (UbL), ubiquitin-associated domain 1 (UbA1), XPC-binding domain and UbA2. The protein encoded by this gene plays an important role in nucleotide excision repair and also in delivery of polyubiquitinated proteins to the proteasome. Alternative splicing results in multiple transcript variants encoding multiple isoforms. [provided by RefSeq, Jun 2012],
Function
domain:The ubiquitin-like domain mediates interaction with MJD.,function:Involved in postreplication repair of UV-damaged DNA. Postreplication repair functions in gap-filling of a daughter strand on replication of damaged DNA .,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the RAD23 family.,similarity:Contains 1 ubiquitin-like domain.,similarity:Contains 2 UBA domains.,subunit:Interacts with MJD. Interacts with HIV-1 Vpr.,
Protein name
UV excision repair protein RAD23 homolog A
Other name
RAD23A; UV excision repair protein RAD23 homolog A; HR23A; hHR23A
Fields
>>Nucleotide excision repair;>>Protein processing in endoplasmic reticulum
Human protein sequence Database
P54725
Mouse protein sequence database
P54726
Rat protein sequence database
Cellular localization
Nucleus.
Tissue expression
Brain,Pancreas,Testis,
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