Molecular weight (DA)
45kD
Immunogen
The antiserum was produced against synthesized peptide derived from human HORMAD1. AA range:321-370
Specificity
HORMAD1 Polyclonal Antibody detects endogenous levels of HORMAD1 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a HORMA domain-containing protein. HORMA domains are involved in chromatin binding and play a role in cell cycle regulation. The encoded protein may play a role in meiosis, and expression of this gene is a potential marker for cancer. A pseudogene of this gene is located on the long arm of chromosome 6. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010],
Function
similarity:Contains 1 HORMA domain.,tissue specificity:Testis-specific. Over-expressed in carcinomas.,
Protein name
HORMA domain-containing protein 1
Other name
HORMAD1; NOHMA; HORMA domain-containing protein 1; Cancer/testis antigen 46; CT46; Newborn ovary HORMA protein
Human protein sequence Database
Q86X24
Mouse protein sequence database
Q9D5T7
Rat protein sequence database
Cellular localization
Nucleus . Chromosome . Preferentially localizes to unsynapsed or desynapsed chromosomal regions during the prophase I stage of meiosis. TRIP13 is required for depletion from synapsed chromosomes. The expression of the phosphorylated form at Ser-377 is restricted to unsynapsed chromosomal regions (By similarity). .
Tissue expression
Testis-specific. Over-expressed in carcinomas.
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