Immunogen
The antiserum was produced against synthesized peptide derived from human DMC1. AA range:61-110
Specificity
Dmc1 Polyclonal Antibody detects endogenous levels of Dmc1 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
IHC: 1/100 - 1/300. ELISA: 1/10000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
DNA meiotic recombinase 1(DMC1) Homo sapiens This gene encodes a member of the superfamily of recombinases (also called DNA strand-exchange proteins). Recombinases are important for repairing double-strand DNA breaks during mitosis and meiosis. This protein, which is evolutionarily conserved, is reported to be essential for meiotic homologous recombination and may thus play an important role in generating diversity of genetic information. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013],
Function
function:May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks.,similarity:Belongs to the recA family. DMC1 subfamily.,similarity:Contains 1 HhH domain.,subunit:Interacts with the MND1-PSMC3IP heterodimer (By similarity). Double stacked ring-shaped homooctamer.,
Protein name
Meiotic recombination protein DMC1/LIM15 homolog
Other name
DMC1; DMC1H; LIM15; Meiotic recombination protein DMC1/LIM15 homolog
Human protein sequence Database
Q14565
Mouse protein sequence database
Q61880
Rat protein sequence database
Cellular localization
Nucleus . Chromosome .
Tissue expression
Ovary,Testis,Thymus,
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